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Evolutionary Insights from a Large-Scale Survey of Population-Genomic Variation.
Ye, Zhiqiang; Wei, Wen; Pfrender, Michael E; Lynch, Michael.
Afiliação
  • Ye Z; Hubei Key Laboratory of Genetic Regulation & Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.
  • Wei W; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287, USA.
  • Pfrender ME; Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Lynch M; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ 85287, USA.
Mol Biol Evol ; 40(11)2023 Nov 03.
Article em En | MEDLINE | ID: mdl-37863047
The field of genomics has ushered in new methods for studying molecular-genetic variation in natural populations. However, most population-genomic studies still rely on small sample sizes (typically, <100 individuals) from single time points, leaving considerable uncertainties with respect to the behavior of relatively young (and rare) alleles and, owing to the large sampling variance of measures of variation, to the specific gene targets of unusually strong selection. Genomic sequences of ∼1,700 haplotypes distributed over a 10-year period from a natural population of the microcrustacean Daphnia pulex reveal evolutionary-genomic features at a refined scale, including previously hidden information on the behavior of rare alleles predicted by recent theory. Background selection, resulting from the recurrent introduction of deleterious alleles, appears to strongly influence the dynamics of neutral alleles, inducing indirect negative selection on rare variants and positive selection on common variants. Temporally fluctuating selection increases the persistence of nonsynonymous alleles with intermediate frequencies, while reducing standing levels of variation at linked silent sites. Combined with the results from an equally large metapopulation survey of the study species, classes of genes that are under strong positive selection can now be confidently identified in this key model organism. Most notable among rapidly evolving Daphnia genes are those associated with ribosomes, mitochondrial functions, sensory systems, and lifespan determination.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Genética Populacional Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Genética Populacional Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article