Early treatment with an M1 and sigma-1 receptor agonist prevents cognitive decline in a transgenic rat model displaying Alzheimer-like amyloid pathology.

Orciani, Chiara; Do Carmo, Sonia; Foret, Morgan K; Hall, Helene; Bonomo, Quentin; Lavagna, Agustina; Huang, Chunwei; Cuello, A Claudio

Orciani, Chiara; Do Carmo, Sonia; Foret, Morgan K; Hall, Helene; Bonomo, Quentin; Lavagna, Agustina; Huang, Chunwei; Cuello, A Claudio.

Afiliação

Orciani C; Department of Neurology and Neurosurgery, McGill University, Montreal H3A 2B4, Canada.
Do Carmo S; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada.
Foret MK; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada.
Hall H; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada.
Bonomo Q; Department of Neurology and Neurosurgery, McGill University, Montreal H3A 2B4, Canada.
Lavagna A; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada.
Huang C; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada.
Cuello AC; Department of Neurology and Neurosurgery, McGill University, Montreal H3A 2B4, Canada; Department of Pharmacology and Therapeutics, McGill University, Montreal H3G 1Y6, Canada; Department of Anatomy and Cell Biology, McGill University, Montreal H3A 0C7, Canada,; Department of Pharmacology, Oxford Un

Neurobiol Aging ; 132: 220-232, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37864952

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Receptores sigma; Ratos; Animais; Camundongos; Doença de Alzheimer/patologia; Ratos Transgênicos; Precursor de Proteína beta-Amiloide; Peptídeos beta-Amiloides; Proteínas Amiloidogênicas; Disfunção Cognitiva/tratamento farmacológico; Disfunção Cognitiva/prevenção & controle; Disfunção Cognitiva/complicações; Placa Amiloide/patologia; Modelos Animais de Doenças; Camundongos Transgênicos; Receptor Sigma-1

Palavras-chave

Alzheimer's disease; Amyloid pathology; Muscarinic agonist; Neuroinflammation; Sigma-1 receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores sigma / Doença de Alzheimer / Disfunção Cognitiva Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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