Scale-up in twin-screw wet granulation: impact of formulation properties.

Franke, Marcel; Riedel, Thomas; Meier, Robin; Schmidt, Carsten; Kleinebudde, Peter

Franke, Marcel; Riedel, Thomas; Meier, Robin; Schmidt, Carsten; Kleinebudde, Peter.

Afiliação

Franke M; Department of Pharmaceutical Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
Riedel T; Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Düsseldorf, Germany.
Meier R; Department of Pharmaceutical Technologies, Merck Healthcare KGaA, Darmstadt, Germany.
Schmidt C; L.B. Bohle Maschinen und Verfahren GmbH, Ennigerloh, Germany.
Kleinebudde P; Department of Pharmaceutical Technologies, Merck Healthcare KGaA, Darmstadt, Germany.

Pharm Dev Technol ; 28(10): 948-961, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37889884

Assuntos

Excipientes; Tecnologia Farmacêutica; Tamanho da Partícula; Solubilidade; Comprimidos; Composição de Medicamentos

Palavras-chave

Continuous manufacturing; continuous fluid bed drying; continuous wet granulation; process scaling; scale-up; twin-screw granulation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tecnologia Farmacêutica / Excipientes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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