Immunogenicity and Tolerability of a SARS-CoV-2 TNX-1800, a Live Recombinant Poxvirus Vaccine Candidate, in Syrian Hamsters and New Zealand White Rabbits.

Awasthi, Mayanka; Macaluso, Anthony; Goebel, Scott J; Luea, Erin; Noyce, Ryan S; Nasar, Farooq; Daugherty, Bruce; Bavari, Sina; Lederman, Seth

Awasthi, Mayanka; Macaluso, Anthony; Goebel, Scott J; Luea, Erin; Noyce, Ryan S; Nasar, Farooq; Daugherty, Bruce; Bavari, Sina; Lederman, Seth.

Afiliação

Awasthi M; Tonix Pharmaceutical, Frederick, MD 21701, USA.
Macaluso A; Tonix Pharmaceutical, Frederick, MD 21701, USA.
Goebel SJ; Tonix Pharmaceutical, Frederick, MD 21701, USA.
Luea E; Southern Research, Birmingham, AL 35205, USA.
Noyce RS; Department of Medical Microbiology & Immunology, Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Nasar F; Tonix Pharmaceutical, Frederick, MD 21701, USA.
Daugherty B; Tonix Pharmaceuticals, Chatham, NJ 07928, USA.
Bavari S; Tonix Pharmaceutical, Frederick, MD 21701, USA.
Lederman S; Tonix Pharmaceuticals, Dartmouth, MA 02745, USA.

Viruses ; 15(10)2023 10 21.

Article em En | MEDLINE | ID: mdl-37896908

Assuntos

COVID-19; Poxviridae; Cricetinae; Coelhos; Animais; Mesocricetus; SARS-CoV-2/genética; Vacinas Atenuadas/efeitos adversos; Vacinas Sintéticas/efeitos adversos; Vacinas Sintéticas/genética; Anticorpos Antivirais; Imunoglobulina G; Glicoproteína da Espícula de Coronavírus/genética; Anticorpos Neutralizantes

Palavras-chave

IgG; SARS-CoV-2; TNX-1800; antibody titer; horsepox; immunogenicity; spike protein; vaccine; vaccine platform

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poxviridae / COVID-19 Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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