The utilization of molecular microscope in management of heart transplant recipients in the era of noninvasive monitoring.
Clin Transplant
; 37(12): e15131, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37897211
ABSTRACT
INTRODUCTION:
Monitoring for graft rejection is a fundamental tenet of post-transplant follow-up. In heart transplantation (HT) in particular, rejection has been traditionally assessed with endomyocardial biopsy (EMB). EMB has potential complications and noted limitations, including interobserver variability in interpretation. Additional tests, such as basic cardiac biomarkers, cardiac imaging, gene expression profiling (GEP) scores, donor-derived cell-free DNA (dd-cfDNA) and the novel molecular microscope diagnostic system (MMDx) have become critical tools in rejection surveillance beyond standard EMB.METHODS:
This paper describes an illustrative case followed by a review of MMDx within the context of other noninvasive screening modalities for rejection.CONCLUSIONS:
We suggest MMDx be used to assist with early detection of rejection in cases of discordance between EMB and other noninvasive studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Coração
/
Miocárdio
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article