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Clade 2.3.4.4 H5 chimeric cold-adapted attenuated influenza vaccines induced cross-reactive protection in mice and ferrets.
Sun, Weiyang; Xu, Jiaqi; Wang, Zhenfei; Li, Dongxu; Sun, Yue; Zhu, Menghan; Liu, Xiawei; Li, Yuanguo; Li, Fangxu; Wang, Tiecheng; Feng, Na; Guo, Zhendong; Xia, Xianzhu; Gao, Yuwei.
Afiliação
  • Sun W; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Xu J; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Wang Z; Key Laboratory of Animal Resistant Biology of Shandong, College of Life Sciences,Shandong Normal University , Jinan, China.
  • Li D; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Sun Y; Jilin Agricultural University , Changchun, China.
  • Zhu M; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Liu X; College of Veterinary Medicine, Shanxi Agricultural University , Jinzhong, Shanxi, China.
  • Li Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Li F; Jilin Province Key Laboratory on Chemistry and Biology of Changbai Mountain Natural Drugs, School of Life Sciences, Northeast Normal University , Changchun, China.
  • Wang T; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Feng N; Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, School of Basic Medical Sciences , Kaifeng, China.
  • Guo Z; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
  • Xia X; Henan International Joint Laboratory for Nuclear Protein Regulation, Henan University, School of Basic Medical Sciences , Kaifeng, China.
  • Gao Y; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Changchun, China.
J Virol ; 97(11): e0110123, 2023 Nov 30.
Article em En | MEDLINE | ID: mdl-37916835
ABSTRACT
IMPORTANCE Clade 2.3.4.4 H5Nx avian influenza viruses (AIVs) have circulated globally and caused substantial economic loss. Increasing numbers of humans have been infected with Clade 2.3.4.4 H5N6 AIVs in recent years. Only a few human influenza vaccines have been licensed to date. However, the licensed live attenuated influenza virus vaccine exhibited the potential of being recombinant with the wild-type influenza A virus (IAV). Therefore, we developed a chimeric cold-adapted attenuated influenza vaccine based on the Clade 2.3.4.4 H5 AIVs. These H5 vaccines demonstrate the advantage of being non-recombinant with circulated IAVs in the future influenza vaccine study. The findings of our current study reveal that these H5 vaccines can induce cross-reactive protective efficacy in mice and ferrets. Our H5 vaccines may provide a novel option for developing human-infected Clade 2.3.4.4 H5 AIV vaccines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vacinas contra Influenza / Infecções por Orthomyxoviridae / Proteção Cruzada Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vacinas contra Influenza / Infecções por Orthomyxoviridae / Proteção Cruzada Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article