Compositional analysis of microbiome data using the linear decomposition model (LDM).
Bioinformatics
; 39(11)2023 11 01.
Article
em En
| MEDLINE
| ID: mdl-37930883
ABSTRACT
SUMMARY:
There are compelling reasons to test compositional hypotheses about microbiome data. We present here linear decomposition model-centered log ratio (LDM-clr), an extension of our LDM approach to allow fitting linear models to centered-log-ratio-transformed taxa count data. As LDM-clr is implemented within the existing LDM program, this extension enjoys all the features supported by LDM, including a compositional analysis of differential abundance at both the taxon and community levels, while allowing for a wide range of covariates and study designs for either association or mediation analysis. AVAILABILITY AND IMPLEMENTATION LDM-clr has been added to the R package LDM, which is available on GitHub at https//github.com/yijuanhu/LDM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Microbiota
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article