Epigenome-wide studies of antipsychotics: a systematic review and pathway meta-analysis.

Antipsychotics are a medication used for the treatment of individuals with schizophrenia and bipolar disorder. Antipsychotics work well, but some patients do not respond to treatment and some get side effects from the treatment, and we are not sure why. A possible reason could be how marks on our DNA interact with antipsychotics in a process called epigenetics. This area of research has been ongoing but requires a summary and report of the results together. This review aims to provide such a report so that one day antipsychotic treatment can be improved so that more patients respond and fewer get side effects.