Effects of different insulin sensitisers in the management of polycystic ovary syndrome: A systematic review and meta-analysis.
Clin Endocrinol (Oxf)
; 100(2): 149-163, 2024 02.
Article
em En
| MEDLINE
| ID: mdl-37933831
ABSTRACT
OBJECTIVE:
Characteristic features of polycystic ovary syndrome (PCOS) include insulin resistance and an increased risk for type 2 diabetes. To promote improved insulin sensitivity, insulin sensitisers have been used in PCOS. However, direct comparisons across these agents are limited. This study compared the effects of metformin, rosiglitazone and pioglitazone in the management of PCOS to inform the 2023 International Evidence-based PCOS Guideline.DESIGN:
Systematic review and meta-analysis of the literature. PATIENTS Women with PCOS and treatment with insulin sensitisers. MEASUREMENTS Hormonal and clinical outcomes, as well as side effects.RESULTS:
Of 1660 publications identified, 13 randomised controlled trials were included. Metformin was superior in lowering weight (mean difference [MD] -4.39, 95% confidence interval [CI] -7.69 to -1.08 kg), body mass index (MD -0.95, 95% CI -1.41 to -0.49 kg/m2 ) and testosterone (MD -0.10, 95% CI -0.18 to -0.03 nmol/L) versus rosiglitazone, whereas there was no difference when comparing metformin to pioglitazone. Adding rosiglitazone or pioglitazone to metformin did not improve metabolic outcomes. However, rosiglitazone seemed superior to metformin in lowering lipid concentrations.CONCLUSIONS:
Metformin should remain the first-line insulin sensitising treatment in adults with PCOS for the prevention and management of weight and metabolic features. The addition of thiazolidinediones appears to offer little benefit.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
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Resistência à Insulina
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Tiazolidinedionas
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Diabetes Mellitus Tipo 2
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Metformina
Tipo de estudo:
Systematic_reviews
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article