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Gold(I)-Mediated Radioiododecarboxylation of Arenes.
Bloux, Hugo; Khouya, Ahmed Ait; Sopkova-de Oliveira Santos, Jana; Fabis, Frédéric; Dubost, Emmanuelle; Cailly, Thomas.
Afiliação
  • Bloux H; Centre d'Etudes et de Recherche sur le Medicament de Normandie, Normandie Université, Caen 14000, France.
  • Khouya AA; Centre d'Etudes et de Recherche sur le Medicament de Normandie, Normandie Université, Caen 14000, France.
  • Sopkova-de Oliveira Santos J; Centre d'Etudes et de Recherche sur le Medicament de Normandie, Normandie Université, Caen 14000, France.
  • Fabis F; Centre d'Etudes et de Recherche sur le Medicament de Normandie, Normandie Université, Caen 14000, France.
  • Dubost E; Centre d'Etudes et de Recherche sur le Medicament de Normandie, Normandie Université, Caen 14000, France.
  • Cailly T; Institut Blood and Brain @ Caen Normandie (BB@C), Caen 14000, France.
Org Lett ; 25(45): 8100-8104, 2023 Nov 17.
Article em En | MEDLINE | ID: mdl-37933839
ABSTRACT
A novel radioiodination method is developed using carboxylic acids as radiolabeling precursors. This method involves decarboxylation and organogold(I) intermediate formation, enabling efficient radioiodination of (hetero)arenes and cinnamic and phenylpropiolic acids. Additionally, we demonstrated the prolonged stability of crude gold(I) organometallic compounds, showcasing their enduring radiolabeling capabilities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article