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Cattle-derived knob paratopes grafted onto peripheral loops of the IgG1 Fc region enable the generation of a novel symmetric bispecific antibody format.
Yanakieva, Desislava; Vollmer, Lena; Evers, Andreas; Siegmund, Vanessa; Arras, Paul; Pekar, Lukas; Doerner, Achim; Valldorf, Bernhard; Kolmar, Harald; Zielonka, Stefan; Krah, Simon.
Afiliação
  • Yanakieva D; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Vollmer L; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Evers A; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Siegmund V; Early Protein Supply and Characterization, Merck Healthcare KGaA, Darmstadt, Germany.
  • Arras P; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Pekar L; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Doerner A; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Valldorf B; Targeted mRNA Delivery, Merck KGaA, Darmstadt, Germany.
  • Kolmar H; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.
  • Zielonka S; Antibody Discovery and Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.
  • Krah S; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.
Front Immunol ; 14: 1238313, 2023.
Article em En | MEDLINE | ID: mdl-37942319
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Anticorpos Biespecíficos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Anticorpos Biespecíficos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article