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Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.
Raux, Brigitt; Buchan, Karly A; Bennett, James; Christott, Thomas; Dowling, Matthew S; Farnie, Gillian; Fedorov, Oleg; Gamble, Vicki; Gileadi, Carina; Giroud, Charline; Huber, Kilian V M; Korczynska, Magdalena; Limberakis, Chris; Narayanan, Arjun; Owen, Dafydd R; Sáez, Laura Díaz; Stock, Ingrid A; Londregan, Allyn T.
Afiliação
  • Raux B; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Buchan KA; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Bennett J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Christott T; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Dowling MS; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
  • Farnie G; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Fedorov O; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Gamble V; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Gileadi C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Giroud C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Huber KVM; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Korczynska M; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
  • Limberakis C; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
  • Narayanan A; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
  • Owen DR; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA.
  • Sáez LD; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
  • Stock IA; Pfizer Worldwide Research and Development, Groton, CT 06340, USA.
  • Londregan AT; Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA. Electronic address: allyn.t.londregan@pfizer.com.
Bioorg Med Chem Lett ; 98: 129546, 2024 Jan 15.
Article em En | MEDLINE | ID: mdl-37944866
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Histonas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Histonas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article