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Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury.
Andrianov, Viacheslav V; Kulchitsky, Vladimir A; Yafarova, Guzel G; Bazan, Leah V; Bogodvid, Tatiana K; Deryabina, Irina B; Muranova, Lyudmila N; Silantyeva, Dinara I; Arslanov, Almaz I; Paveliev, Mikhail N; Fedorova, Ekaterina V; Filipovich, Tatiana A; Nagibov, Aleksei V; Gainutdinov, Khalil L.
Afiliação
  • Andrianov VV; Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia.
  • Kulchitsky VA; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Yafarova GG; Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus.
  • Bazan LV; Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia.
  • Bogodvid TK; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Deryabina IB; Zavoisky Physical-Technical Institute of the Russian Academy of Sciences, 420000 Kazan, Russia.
  • Muranova LN; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Silantyeva DI; Department of Biomedical Sciences, Volga Region State University of Physical Culture, Sport and Tourism, 420000 Kazan, Russia.
  • Arslanov AI; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Paveliev MN; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Fedorova EV; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Filipovich TA; Department of Human and Animals, Institute of Fundamental Medicine and Biology, Kazan Federal University, 420000 Kazan, Russia.
  • Nagibov AV; Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland.
  • Gainutdinov KL; Brain Center, Institute of Physiology, National Academy of Sciences, 220012 Minsk, Belarus.
Molecules ; 28(21)2023 Oct 31.
Article em En | MEDLINE | ID: mdl-37959778
Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Lesões Encefálicas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Lesões Encefálicas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article