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Efficient cross-protection against serotype 4/8a fowl adenoviruses (FAdVs): recombinant FAdV-4 with FAdV-8a Fiber.
Lu, Yixuan; Yuan, Yaqin; Jiang, Huiru; Xu, Zhenqi; Guo, Yiwen; Cao, Xudong; Li, Tuofan; Wan, Zhimin; Shao, Hongxia; Qin, Aijian; Xie, Quan; Ye, Jianqiang.
Afiliação
  • Lu Y; Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.
  • Yuan Y; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses , Yangzhou, Jiangsu, China.
  • Jiang H; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.
  • Xu Z; Institutes of Agricultural Science and Technology Development, Yangzhou University , Yangzhou, Jiangsu, China.
  • Guo Y; Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.
  • Cao X; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses , Yangzhou, Jiangsu, China.
  • Li T; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.
  • Wan Z; Institutes of Agricultural Science and Technology Development, Yangzhou University , Yangzhou, Jiangsu, China.
  • Shao H; Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University , Yangzhou, Jiangsu, China.
  • Qin A; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses , Yangzhou, Jiangsu, China.
  • Xie Q; Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University , Yangzhou, Jiangsu, China.
  • Ye J; Institutes of Agricultural Science and Technology Development, Yangzhou University , Yangzhou, Jiangsu, China.
Microbiol Spectr ; 11(6): e0246223, 2023 Dec 12.
Article em En | MEDLINE | ID: mdl-37966208
ABSTRACT
IMPORTANCE Epidemiological data reveal that FAdV-4 and FAdV-8a are the dominant serotypes of FAdVs in the poultry industry in China. Although three commercial inactivated vaccines against FAdV-4 have been licensed in China, the bivalent vaccine against both FAdV-4 and FAdV-8a is not available. Here, we used CRISPR-Cas9 and Cre-LoxP system to generate a recombinant virus FAdV4-F/8a-rF2 expressing the Fiber of FAdV-8a. Notably, FAdV4-F/8a-rF2 was highly attenuated and could provide efficient protection against both FAdV-4 and FAdV-8a in the chicken infection model, highlighting the applaudable application of FAdV4-F/8a-rF2 as a novel live-attenuated bivalent vaccine against the diseases caused by the infection of FAdV-4 and FAdV-8a.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Aves Domésticas / Infecções por Adenoviridae / Aviadenovirus Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Aves Domésticas / Infecções por Adenoviridae / Aviadenovirus Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article