Sesquiterpenoids and bibenzyl derivative from Dendrobium hercoglossum.
Fitoterapia
; 172: 105748, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37967770
ABSTRACT
Three new sesquiterpenoids, dendrohercoglin A - C (1-3), and one new bibenzyl derivative, dendronbiline D (4), together with nine known sesquiterpenoids (5-13) were isolated from Dendrobium hercoglossum. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and ECD calculations. All the compounds were evaluated for their neuroprotective and anti-inflammatory activities. Compounds 2 and 3 increased the H2O2-damaged SH-SY5Y cell viabilities from 43.3% to 58.6% and 68.4%, respectively. Compound 4 exhibited pronounced anti-inflammatory activity with IC50 value of 9.5 ± 0.45 µM which was superior to the reference compound quercetin (IC50 15.7 ± 0.89 µM).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Bibenzilas
/
Dendrobium
/
Neuroblastoma
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article