Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance.

Bordeleau, Emily; Stogios, Peter J; Evdokimova, Elena; Koteva, Kalinka; Savchenko, Alexei; Wright, Gerard D

Bordeleau, Emily; Stogios, Peter J; Evdokimova, Elena; Koteva, Kalinka; Savchenko, Alexei; Wright, Gerard D.

Afiliação

Bordeleau E; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Stogios PJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Evdokimova E; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Koteva K; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Savchenko A; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
Wright GD; Center for Structural Genomics of Infectious Diseases (CSGID) University of Calgary, Calgary, Alberta, Canada.

Nat Chem Biol ; 20(2): 234-242, 2024 Feb.

Article em En | MEDLINE | ID: mdl-37973888

Assuntos

Aminoglicosídeos; Histidina; Aminoglicosídeos/farmacologia; Antibacterianos/farmacologia; Antibacterianos/química; Acetiltransferases/genética; Acetiltransferases/metabolismo; Bactérias/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aminoglicosídeos / Histidina Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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