Deep mutational scanning highlights a role for cytosolic regions in Hrd1 function.

Peterson, Brian G; Hwang, Jiwon; Russ, Jennifer E; Schroeder, Jeremy W; Freddolino, P Lydia; Baldridge, Ryan D

Peterson, Brian G; Hwang, Jiwon; Russ, Jennifer E; Schroeder, Jeremy W; Freddolino, P Lydia; Baldridge, Ryan D.

Afiliação

Peterson BG; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Hwang J; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Russ JE; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Schroeder JW; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA.
Freddolino PL; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Computational Medicine
Baldridge RD; Department of Biological Chemistry, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA; Cellular and Molecular Biology Program, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address: ryanbald@umich.e

Cell Rep ; 42(11): 113451, 2023 11 28.

Article em En | MEDLINE | ID: mdl-37980570

Assuntos

Proteínas; Ubiquitina-Proteína Ligases; Ubiquitinação; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo; Proteínas/metabolismo; Degradação Associada com o Retículo Endoplasmático; Retículo Endoplasmático/metabolismo; Ubiquitina/metabolismo

Palavras-chave

CP: Cell biology; ERAD; UPS; deep mutational scanning; endoplasmic reticulum-associated degradation; multiplexed high-throughput screening; protein degradation; protein disorder; retrotranslocation; ubiquitin-proteasome system

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas / Ubiquitina-Proteína Ligases Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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