DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε.
J Virol
; 97(12): e0150123, 2023 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-37982618
ABSTRACT
IMPORTANCE The type-I interferon (IFN-I) signaling pathway is the first line of antiviral innate immunity. It must be precisely regulated against virus-induced damage. The tightly regulated mechanisms of action of host genes in the antiviral innate immune signaling pathway are still worth studying. Here, we report a novel role of DLG1 in positively regulating the IκB kinase epsilon (IKKε)-mediated IFN-I signaling response against negative-stranded RNA virus replication, whereas the RNA virus inhibits the expression of DLG1 for immune escape. Importantly, the E3 ligase March2 interacts with and promotes K27-linked polyubiquitination of IKKε, and p62 is a cargo receptor that recognizes ubiquitinated IKKε for eventual autophagic degradation. Together, the current findings elucidate the role of DLG1 in the antiviral IFN-I signaling pathway and viral infection repression.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Viroses
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Quinase I-kappa B
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Proteína Sequestossoma-1
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Proteína 1 Homóloga a Discs-Large
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Vírus de RNA de Sentido Negativo
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Imunidade Inata
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article