Downregulation of Gadd45ß alleviates osteoarthritis by repressing lipopolysaccharide-induced fibroblast-like synoviocyte inflammation, proliferation and migration.

Wu, Suyu; Guo, Wenwen; Chen, Ling; Lin, Xinxin; Tang, Minjie; Lin, Cheng; Guo, Hanzhi; Zhang, Tianwen; Gao, Yao

Wu, Suyu; Guo, Wenwen; Chen, Ling; Lin, Xinxin; Tang, Minjie; Lin, Cheng; Guo, Hanzhi; Zhang, Tianwen; Gao, Yao.

Afiliação

Wu S; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China.
Guo W; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China.
Chen L; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China.
Lin X; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China; Department of Pathology, Fuzhou Second Hospital, Fuzhou 350007, Fujian, China.
Tang M; Department of Laboratory Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian, China.
Lin C; The School of Health, Fujian Medical University, Fuzhou 350122, Fujian, China.
Guo H; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China.
Zhang T; Fujian Fishery Resources Monitoring Center, Fuzhou 350003, Fujian, China.
Gao Y; The School of Medical Technology and Engineering, Fujian Medical University, Fuzhou 350122, Fujian, China; Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou 350004, Fujian, China. Electronic address: yaogao@fjmu.ed

Int Immunopharmacol ; 126: 111202, 2024 Jan 05.

Article em En | MEDLINE | ID: mdl-37988908

Assuntos

Osteoartrite; Sinoviócitos; Animais; Ratos; Proliferação de Células; Células Cultivadas; Regulação para Baixo; Fibroblastos; Inflamação/metabolismo; Lipopolissacarídeos/farmacologia; NF-kappa B/metabolismo; Osteoartrite/metabolismo

Palavras-chave

Fibroblast-like synoviocyte; Gadd45ß; Lipopolysaccharide; Nuclear factor -κB; Osteoarthritis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Sinoviócitos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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