Chromatin-mediated silencing on the inactive X chromosome.
Development
; 150(22)2023 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-37991053
ABSTRACT
In mammals, the second X chromosome in females is silenced to enable dosage compensation between XX females and XY males. This essential process involves the formation of a dense chromatin state on the inactive X (Xi) chromosome. There is a wealth of information about the hallmarks of Xi chromatin and the contribution each makes to silencing, leaving the tantalising possibility of learning from this knowledge to potentially remove silencing to treat X-linked diseases in females. Here, we discuss the role of each chromatin feature in the establishment and maintenance of the silent state, which is of crucial relevance for such a goal.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inativação do Cromossomo X
/
RNA Longo não Codificante
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article