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Whole-body MRI for the investigation of joint involvement in inflammatory arthritis.
Freeston, Jane; Marzetti, Matthew; Larkman, Neal; Rowbotham, Emma; Emery, Paul; Grainger, Andrew.
Afiliação
  • Freeston J; Leeds NIHR Musculoskeletal Biomedical Research Centre, Leeds, UK.
  • Marzetti M; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  • Larkman N; Leeds NIHR Musculoskeletal Biomedical Research Centre, Leeds, UK. m.marzetti@nhs.net.
  • Rowbotham E; Department of Medical Physics, Leeds Teaching Hospitals NHS Trust, Leeds, UK. m.marzetti@nhs.net.
  • Emery P; Department of Radiology, Harrogate and District NHS Foundation Trust, Harrogate, UK.
  • Grainger A; Leeds NIHR Musculoskeletal Biomedical Research Centre, Leeds, UK.
Skeletal Radiol ; 53(5): 935-945, 2024 May.
Article em En | MEDLINE | ID: mdl-37991554
ABSTRACT

OBJECTIVES:

This study aimed to develop a novel whole-body MRI protocol capable of assessing inflammatory arthritis at an early stage in multiple joints in one examination. MATERIALS AND

METHODS:

Forty-six patients with inflammatory joint symptoms and 9 healthy volunteers underwent whole-body MR imaging on a 3.0 T MRI scanner in this prospective study. Image quality and pathology in each joint, bursae, entheses and tendons were scored by two of three radiologists and compared to clinical joint scores. Participants were divided into three groups based on diagnosis at 1-year follow-up (healthy volunteers, rheumatoid arthritis and all other types of arthritis). Radiology scores were compared between the three groups using a Kruskal-Wallis test. The clinical utility of radiology scoring was compared to clinical scoring using ROC analysis.

RESULTS:

A protocol capable of whole-body MR imaging of the joints with an image acquisition time under 20 min was developed with excellent image quality. Synovitis scores were significantly higher in patients who were diagnosed with rheumatoid arthritis at 12 months (p < 0.05). Radiology scoring of bursitis showed statistically significant differences between each of the three groups-healthy control, rheumatoid arthritis and non-rheumatoid arthritis (p < 0.05). There was no statistically significant difference in ROC analysis between MRI and clinical scores.

CONCLUSION:

This study has developed a whole-body MRI joint imaging protocol that is clinically feasible and shows good differentiation of joint pathology between healthy controls, patients with rheumatoid arthritis and patients with other forms of arthritis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Sinovite Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Sinovite Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article