Evidence for the contribution of the gut microbiome to obesity and its reversal.
Sci Transl Med
; 15(723): eadg2773, 2023 11 22.
Article
em En
| MEDLINE
| ID: mdl-37992156
ABSTRACT
Obesity has become a worldwide pandemic affecting more than 650 million people and is associated with a high burden of morbidity. Alongside traditional risk factors for obesity, the gut microbiome has been identified as a potential factor in weight regulation. Although rodent studies suggest a link between the gut microbiome and body weight, human evidence for causality remains scarce. In this Review, we postulate that existing evidence remains to establish a contribution of the gut microbiome to the development of obesity in humans but that modified probiotic strains and supraphysiological dosages of microbial metabolites may be beneficial in combatting obesity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Probióticos
/
Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article