ß-Cyclodextrin based Pickering emulsions for α-tocopherol delivery: Antioxidation stability and bioaccessibility.

ABSTRACT

ß-Cyclodextrin (ß-CD) Pickering emulsion and cinnamaldehyde/ß-cyclodextrin (CIN/ß-CD) Pickering emulsion were prepared and the influences of oxidation and digestion were investigated. CIN/ß-CD composite was better dispersed at the oil-water interface than ß-CD. Hydrophobic group of CIN anchored in the oil phase and Hydrophilic hydroxyl group of ß-CD extended into the aqueous phase, which allowed CIN/ß-CD composite to be oriented at the oil-water interface and formed a more stable oil-water interface layer. ß-CD Pickering emulsion was more susceptible to oxidative deterioration than CIN/ß-CD Pickering emulsion, its malondialdehyde (MDA) value was as high as 509.41 ± 9.37 nmol/L. Digestion experiment indicated that CIN/ß-CD Pickering emulsion was released inner oil phase in the small intestine and free fatty acid (FFA) release rate was 44.32 ± 1.08%. Pharmacokinetic parameters manifested that α-tocopherol peak concentration (Cmax) was 64.32 ± 6.45 mg/L and the peak time (Tmax) appeared at 5 h after administration of CIN/ß-CD Pickering emulsion.