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Evaluating 17 methods incorporating biological function with GWAS summary statistics to accelerate discovery demonstrates a tradeoff between high sensitivity and high positive predictive value.
Moore, Amy; Marks, Jesse A; Quach, Bryan C; Guo, Yuelong; Bierut, Laura J; Gaddis, Nathan C; Hancock, Dana B; Page, Grier P; Johnson, Eric O.
Afiliação
  • Moore A; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA. almoore@rti.org.
  • Marks JA; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA.
  • Quach BC; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA.
  • Guo Y; GeneCentric Therapeutics, Inc., Cary, NC, USA.
  • Bierut LJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Gaddis NC; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA.
  • Hancock DB; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA.
  • Page GP; Genomics and Translational Research Center, RTI International, Research Triangle Park, NC, 27709, USA.
  • Johnson EO; Fellow Program, RTI International, Research Triangle Park, NC, 27709, USA.
Commun Biol ; 6(1): 1199, 2023 11 24.
Article em En | MEDLINE | ID: mdl-38001305
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo de Nucleotídeo Único / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2023 Tipo de documento: Article