[Research status and challenges of advanced myeloproliferative neoplasms].
Zhonghua Yi Xue Za Zhi
; 103(45): 3603-3607, 2023 Dec 05.
Article
em Zh
| MEDLINE
| ID: mdl-38018058
ABSTRACT
Classical myeloproliferative neoplasms (MPN), also known as Ph-MPN, includes polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Secondary myelofibrosis (sMF) and secondary acute myeloid leukemia (sAML) are important disease progressions of MPN. After MPN disease progression, hematopoietic stem cells undergo new clonal evolution, leading to drug resistance, poor treatment effect and poor survival of patients. In recent years, the exploration of the mechanism of disease progression and the precise diagnosis and treatment of MPN have attracted much attention. This article summarizes the research status of MPN disease progression, including the pathogenesis, risk stratification, and precision treatment, in order to provide reference for exploring new diagnosis and treatment methods of MPN disease progression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Mielofibrose Primária
/
Trombocitemia Essencial
/
Transtornos Mieloproliferativos
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2023
Tipo de documento:
Article