Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair.

Altwerger, Gary; Ghazarian, Maddie; Glazer, Peter M

Altwerger, Gary; Ghazarian, Maddie; Glazer, Peter M.

Afiliação

Altwerger G; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA.
Ghazarian M; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06511, USA.
Glazer PM; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06511, USA; Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA. Electronic address: peter.glazer@yale.edu.

Semin Cancer Biol ; 98: 11-18, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38029867

Assuntos

Antineoplásicos; Neoplasias; Humanos; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Inibidores de Poli(ADP-Ribose) Polimerases/uso terapêutico; Poli(ADP-Ribose) Polimerases/metabolismo; Poli(ADP-Ribose) Polimerases/farmacologia; Reparo do DNA; Antineoplásicos/farmacologia; Neoplasias/tratamento farmacológico; Neoplasias/genética; Hipóxia/genética; Microambiente Tumoral

Palavras-chave

BRCA; Cediranib; DNA repair; Homologous recombination; Hypoxia; Immune checkpoint inhibitors; Immune therapy; RAD51; Synthetic lethality

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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