Ubiquitination-dependent degradation of nucleolin mediated by porcine circovirus type 3 capsid protein.
J Virol
; 97(12): e0089423, 2023 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-38032196
ABSTRACT
IMPORTANCE Porcine circovirus type 3 (PCV3) is an emerging pathogen that causes multisystem disease in pigs and poses a severe threat to the swine industry. However, the mechanisms of how PCV3 uses host proteins to regulate its own life cycle are not well understood. In this study, we found that PCV3 capsid protein interacts with nucleolin and degrades it. Degradation of nucleolin by the PCV3 capsid protein requires recruitment of the enzyme RNF34, which is transported to the nucleolus from the cytoplasm in the presence of the PCV3 capsid protein. Nucleolin also decreases PCV3 replication by promoting the release of interferon ß. These findings clarify the mechanism by which nucleolin modulates PCV3 replication in cells, thereby facilitating to provide an important strategy for preventing and controlling PCV3 infection.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Suínos
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Circovirus
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Infecções por Circoviridae
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Proteínas do Capsídeo
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Nucleolina
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article