SeMet alleviates AFB<sub>1</sub>-induced oxidative stress and apoptosis in rabbit kidney by regulating Nrf2//Keap1/NQO1 and PI3K/AKT signaling pathways.

Liu, Yumei; Wang, Jianing; Chang, Zhaoyang; Li, Shuangjun; Zhang, Zhikai; Liu, Shiyang; Wang, Shuaishuai; Wei, Lan; Lv, Qiongxia; Ding, Ke; Zhang, Ziqiang

SeMet alleviates AFB₁-induced oxidative stress and apoptosis in rabbit kidney by regulating Nrf2//Keap1/NQO1 and PI3K/AKT signaling pathways.

Liu, Yumei; Wang, Jianing; Chang, Zhaoyang; Li, Shuangjun; Zhang, Zhikai; Liu, Shiyang; Wang, Shuaishuai; Wei, Lan; Lv, Qiongxia; Ding, Ke; Zhang, Ziqiang.

Afiliação

Liu Y; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Wang J; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Chang Z; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Li S; Henan Delin Biological Products Co., Ltd, China.
Zhang Z; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Liu S; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Wang S; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Wei L; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Lv Q; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Ding K; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Zhang Z; College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China. Electronic address: ziqiangzhang@haust.edu.cn.

Ecotoxicol Environ Saf ; 269: 115742, 2024 Jan 01.

Article em En | MEDLINE | ID: mdl-38039849

Assuntos

Rim; Estresse Oxidativo; Selenometionina; Animais; Coelhos; Antioxidantes/farmacologia; Antioxidantes/metabolismo; Apoptose/efeitos dos fármacos; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Rim/patologia; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Selenometionina/farmacologia; Aflatoxina B1/toxicidade; NAD(P)H Desidrogenase (Quinona)/efeitos dos fármacos; NAD(P)H Desidrogenase (Quinona)/metabolismo

Palavras-chave

Mycotoxin; Nrf2/Keap1/NQO1; Oxidative stress; PI3K/AKT; SeMet; Tissue damage

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selenometionina / Estresse Oxidativo / Rim Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google