Sodium butyrate ameliorates sepsis-associated lung injury by enhancing gut and lung barrier function in combination with modulation of CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells.

Wei, Yuting; Li, Tingting; Zhao, Dengming; Sun, Tian; Ma, Can; Zhang, Lijuan; Lv, Shihua; Li, Jingbo; Tan, Jing; Li, Wenzhi

Sodium butyrate ameliorates sepsis-associated lung injury by enhancing gut and lung barrier function in combination with modulation of CD4⁺Foxp3⁺ regulatory T cells.

Wei, Yuting; Li, Tingting; Zhao, Dengming; Sun, Tian; Ma, Can; Zhang, Lijuan; Lv, Shihua; Li, Jingbo; Tan, Jing; Li, Wenzhi.

Afiliação

Wei Y; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Li T; Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510000, Guangdong, PR China.
Zhao D; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Sun T; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Ma C; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Zhang L; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Lv S; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Li J; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Tan J; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China.
Li W; Department of Anesthesiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150080, Heilongjiang, PR China. Electronic address: wenzhili9@126.com.

Eur J Pharmacol ; 963: 176219, 2024 Jan 15.

Article em En | MEDLINE | ID: mdl-38040079

Assuntos

Lesão Pulmonar Aguda; Sepse; Camundongos; Animais; Lesão Pulmonar Aguda/etiologia; Lesão Pulmonar Aguda/complicações; Ácido Butírico/farmacologia; Ácido Butírico/uso terapêutico; Ácido Butírico/metabolismo; Anfirregulina/metabolismo; Linfócitos T Reguladores/metabolismo; Lipopolissacarídeos/metabolismo; Proteína D Associada a Surfactante Pulmonar/metabolismo; Pulmão/patologia; Citocinas/metabolismo; Fatores de Transcrição/metabolismo; Sepse/complicações; Sepse/tratamento farmacológico; Sepse/metabolismo; Fatores de Transcrição Forkhead/metabolismo

Palavras-chave

Cell junction; Gut-lung axis; Regulatory T cell; Sepsis-associated lung injury; Sodium butyrate

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sepse / Lesão Pulmonar Aguda Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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