Prognostic factors for intermediate- or high-risk neuroblastomas in children in China.
BMC Pediatr
; 23(1): 617, 2023 12 06.
Article
em En
| MEDLINE
| ID: mdl-38053080
ABSTRACT
BACKGROUND:
Evidence regarding the characteristics and prognosis of neuroblastoma (NBL) in China is limited. We aimed to investigate the characteristics and prognosis of intermediate- or high-risk NBL in children in China.METHODS:
We included 147 patients with intermediate- or high-risk NBL evaluated from January 2006 to March 2015. The patients were aged 1 month to 15.5 years, 66% of them were boys, and 117 (79.6%) were diagnosed with high-risk NBL.RESULTS:
After a median follow-up of 32.5 months, 80 (45.6%) patients survived, with a median survival time of 48 months (95% confidence interval [CI] 36.41-59.59). High-risk patients (hazard ratio [HR] 12.467; 95% CI 11.029-12.951), partial response (PR) (HR 1.200; 95% CI 1.475-2.509) or progression disease (PD) (HR 1.924; 95% CI 1.623-3.012) after induction chemotherapy, and intracranial metastasis (HR 3.057; 95% CI 0.941-4.892) were independent risk factors for survival (p < 0.05) and postrelapse survival (p < 0.05). NBL relapse, male sex, and PR or PD after induction chemotherapy were risk factors for event-free survival (p < 0.05).CONCLUSIONS:
In addition to previously established independent risk factors, such as age, risk group, and relapse, efficacy of induction chemotherapy and intracranial metastasis play significant roles in the prognosis of NBL.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recidiva Local de Neoplasia
/
Neuroblastoma
Limite:
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article