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High IL2RA/CD25 expression is a prognostic stem cell biomarker for pediatric acute myeloid leukemia without a core-binding factor.
Aoki, Takahiro; Shiba, Norio; Tsujimoto, Shinichi; Yamato, Genki; Hara, Yusuke; Kato, Shota; Yoshida, Kenichi; Ogawa, Seishi; Hayashi, Yasuhide; Iwamoto, Shotaro; Taki, Tomohiko; Shimada, Akira; Iijima-Yamashita, Yuka; Horibe, Keizo; Tawa, Akio; Taga, Takashi; Adachi, Souichi; Tomizawa, Daisuke.
Afiliação
  • Aoki T; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Shiba N; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Tsujimoto S; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Yamato G; Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Hara Y; Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Kato S; Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Yoshida K; Division of Cancer Evolution, National Cancer Center Research Institute, Tokyo, Japan.
  • Ogawa S; Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Hayashi Y; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.
  • Iwamoto S; Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden.
  • Taki T; Institute of Physiology and Medicine, Jobu University, Takasaki, Japan.
  • Shimada A; Department of Pediatrics, Mie University, Tsu, Japan.
  • Iijima-Yamashita Y; Department of Medical Technology, Kyorin University Faculty of Health Sciences, Mitaka, Japan.
  • Horibe K; Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.
  • Tawa A; Clinical Research Center, NHO Nagoya Medical Center, Nagoya, Japan.
  • Taga T; Clinical Research Center, NHO Nagoya Medical Center, Nagoya, Japan.
  • Adachi S; Higashiosaka Aramoto Heiwa Clinic, Higashiosaka, Japan.
  • Tomizawa D; Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan.
Pediatr Blood Cancer ; 71(2): e30803, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38054691
ABSTRACT
CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and an immunotherapy target in acute myeloid leukemia (AML). However, the clinical prevalence and significance of CD25 expression in pediatric AML are unknown. High IL2RA/CD25 expression in pediatric AML showed a stem cell-like phenotype, and elevated CD25 expression was associated with lower overall survival (p < .001) and event-free survival (p < .001) in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. This finding was reproduced in AML without a core-binding factor in the Children's Oncology Group study cohort. High CD25 expression has prognostic significance in pediatric AML.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Fatores de Ligação ao Core Limite: Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Fatores de Ligação ao Core Limite: Child / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article