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Brain Lipids and Lipid Droplet Dysregulation in Alzheimer's Disease and Neuropsychiatric Disorders.
Zhao, Xiaojie; Zhang, Siwei; Sanders, Alan R; Duan, Jubao.
Afiliação
  • Zhao X; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA.
  • Zhang S; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
  • Sanders AR; Center for Psychiatric Genetics, NorthShore University HealthSystem, Evanston, IL, USA.
  • Duan J; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
Complex Psychiatry ; 9(1-4): 154-171, 2023.
Article em En | MEDLINE | ID: mdl-38058955
Background: Lipids are essential components of the structure and for the function of brain cells. The intricate balance of lipids, including phospholipids, glycolipids, cholesterol, cholesterol ester, and triglycerides, is crucial for maintaining normal brain function. The roles of lipids and lipid droplets and their relevance to neurodegenerative and neuropsychiatric disorders (NPDs) remain largely unknown. Summary: Here, we reviewed the basic role of lipid components as well as a specific lipid organelle, lipid droplets, in brain function, highlighting the potential impact of altered lipid metabolism in the pathogenesis of Alzheimer's disease (AD) and NDPs. Key Messages: Brain lipid dysregulation plays a pivotal role in the pathogenesis and progression of neurodegenerative and NPDs including AD and schizophrenia. Understanding the cell type-specific mechanisms of lipid dysregulation in these diseases is crucial for identifying better diagnostic biomarkers and for developing therapeutic strategies aiming at restoring lipid homeostasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article