Biomolecular Condensates as Novel Antiviral Targets.
J Mol Biol
; 436(4): 168380, 2024 02 15.
Article
em En
| MEDLINE
| ID: mdl-38061626
ABSTRACT
Viral infections pose a significant health risk worldwide. There is a pressing need for more effective antiviral drugs to combat emerging novel viruses and the reemergence of previously controlled viruses. Biomolecular condensates are crucial for viral replication and are promising targets for novel antiviral therapies. Herein, we review the role of biomolecular condensates in the viral replication cycle and discuss novel strategies to leverage condensate biology for antiviral drug discovery. Biomolecular condensates may also provide an opportunity to develop antivirals that are broad-spectrum or less prone to acquired drug resistance.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Replicação Viral
/
Viroses
/
Condensados Biomoleculares
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article