Longitudinal modeling of human neuronal aging reveals the contribution of the RCAN1-TFEB pathway to Huntington's disease neurodegeneration.

Lee, Seong Won; Oh, Young Mi; Victor, Matheus B; Yang, Yan; Chen, Shawei; Strunilin, Ilya; Dahiya, Sonika; Dolle, Roland E; Pak, Stephen C; Silverman, Gary A; Perlmutter, David H; Yoo, Andrew S

Lee, Seong Won; Oh, Young Mi; Victor, Matheus B; Yang, Yan; Chen, Shawei; Strunilin, Ilya; Dahiya, Sonika; Dolle, Roland E; Pak, Stephen C; Silverman, Gary A; Perlmutter, David H; Yoo, Andrew S.

Afiliação

Lee SW; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Oh YM; Department of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, USA.
Victor MB; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Yang Y; Department of Biomedical Sciences, Mercer University School of Medicine, Columbus, GA, USA.
Chen S; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Strunilin I; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Dahiya S; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Dolle RE; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Pak SC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Silverman GA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Perlmutter DH; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Yoo AS; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

Nat Aging ; 4(1): 95-109, 2024 Jan.

Article em En | MEDLINE | ID: mdl-38066314

Assuntos

Calcineurina; Doença de Huntington; Humanos; Idoso; Calcineurina/genética; Doença de Huntington/genética; Envelhecimento/genética; Fatores de Transcrição/metabolismo; Corpo Estriado/metabolismo; Proteínas de Ligação a DNA/metabolismo; Proteínas Musculares/genética; Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Calcineurina Limite: Aged / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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