Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl-<i>N</i>-phenethyl Substituted-6,7-benzomorphans and from C8-Hydroxy, Methylene and Methyl Derivatives of <i>N</i>-Phenethylnormetazocine.

Das, Madhurima; Ward, George W; Sulima, Agnieszka; Luo, Dan; Prisinzano, Thomas Edward; Imler, Gregory H; Kerr, Andrew T; Jacobson, Arthur E; Rice, Kenner C

Potent MOR Agonists from 2'-Hydroxy-5,9-dimethyl-N-phenethyl Substituted-6,7-benzomorphans and from C8-Hydroxy, Methylene and Methyl Derivatives of N-Phenethylnormetazocine.

Das, Madhurima; Ward, George W; Sulima, Agnieszka; Luo, Dan; Prisinzano, Thomas Edward; Imler, Gregory H; Kerr, Andrew T; Jacobson, Arthur E; Rice, Kenner C.

Afiliação

Das M; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
Ward GW; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
Sulima A; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
Luo D; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
Prisinzano TE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 S. Limestone Street, Lexington, KY 40536, USA.
Imler GH; Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
Kerr AT; Center for Biomolecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
Jacobson AE; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center
Rice KC; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center

Molecules ; 28(23)2023 Nov 22.

Article em En | MEDLINE | ID: mdl-38067439

Assuntos

Benzomorfanos; Morfina; Benzomorfanos/química; Etilaminas; Indóis; Relação Estrutura-Atividade

Palavras-chave

C8-alkenyl substituted 6,7-benzomorphans; C8-alkyl substituted 6,7-benzomorphans; N-phenethyl analogs of 6,7-benzomorphans; N-phenethylnormetazocine derivatives; inhibition of forskolin-induced cAMP accumulation assay (cAMP assay); opioid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzomorfanos / Morfina Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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