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Targeting Ion Channel TRPM4.
Preti, Barbara; Rougier, Jean-Sébastien; Papapostolou, Irida; Bochen, Florian; Gerber, Christian E; Abriel, Hugues; Lochner, Martin; Peinelt, Christine.
Afiliação
  • Preti B; Institute if Biochemistry and Molecular Medicine, University of Bern.
  • Rougier JS; Institute of Biochemistry and Molecular Medicine, University of Bern.
  • Papapostolou I; Institute of Biochemistry and Molecular Medicine, University of Bern.
  • Bochen F; Institute of Biochemistry and Molecular Medicine, University of Bern.
  • Gerber CE; Institute of Biochemistry and Molecular Medicine, University of Bern.
  • Abriel H; Institute of Biochemistry and Molecular Medicine, University of Bern. hugues.abriel@unibe.ch.
  • Lochner M; Institute of Biochemistry and Molecular Medicine, University of Bern. martin.lochner@unibe.ch.
  • Peinelt C; Institute of Biochemistry and Molecular Medicine, University of Bern. christine.peinelt@ibmm.unibe.ch.
Chimia (Aarau) ; 76(12): 1039-1044, 2022 Dec 21.
Article em En | MEDLINE | ID: mdl-38069800
ABSTRACT
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article