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Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival.
Tzouanas, Constantine N; Sherman, Marc S; Shay, Jessica E S; Rubin, Adam J; Mead, Benjamin E; Dao, Tyler T; Butzlaff, Titus; Mana, Miyeko D; Kolb, Kellie E; Walesky, Chad; Pepe-Mooney, Brian J; Smith, Colton J; Prakadan, Sanjay M; Ramseier, Michelle L; Tong, Evelyn Y; Joung, Julia; Chi, Fangtao; McMahon-Skates, Thomas; Winston, Carolyn L; Jeong, Woo-Jeong; Aney, Katherine J; Chen, Ethan; Nissim, Sahar; Zhang, Feng; Deshpande, Vikram; Lauer, Georg M; Yilmaz, Ömer H; Goessling, Wolfram; Shalek, Alex K.
Afiliação
  • Tzouanas CN; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sherman MS; Harvard-MIT Program in Health Sciences and Technology, Harvard Medical School, Cambridge, MA, USA.
  • Shay JES; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rubin AJ; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Mead BE; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Dao TT; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Butzlaff T; These authors contributed equally.
  • Mana MD; Genetics Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Kolb KE; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Walesky C; These authors contributed equally.
  • Pepe-Mooney BJ; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Smith CJ; Alcohol Liver Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Prakadan SM; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Ramseier ML; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Tong EY; These authors contributed equally.
  • Joung J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chi F; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • McMahon-Skates T; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Winston CL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Jeong WJ; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Aney KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Chen E; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Nissim S; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Zhang F; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Deshpande V; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lauer GM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Yilmaz ÖH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  • Goessling W; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA.
  • Shalek AK; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.
bioRxiv ; 2023 Dec 01.
Article em En | MEDLINE | ID: mdl-38077056
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article