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Therapeutic potential of propolis in alleviating inflammatory response and promoting wound healing in skin burn.
Manginstar, Christian Oktavianus; Tallei, Trina Ekawati; Niode, Nurdjannah Jane; Salaki, Christina Leta; Hessel, Sofia Safitri.
Afiliação
  • Manginstar CO; Entomology Study Program, Postgraduate Program, Sam Ratulangi University, Manado, Indonesia.
  • Tallei TE; Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Sam Ratulangi University, Prof. Dr. R. D. Kandou Central General Hospital, Manado, Indonesia.
  • Niode NJ; Department of Biology, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Manado, Indonesia.
  • Salaki CL; Department of Biology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia.
  • Hessel SS; Department of Dermatology and Venereology, Faculty of Medicine, Sam Ratulangi University, Prof. Dr. R. D. Kandou Central General Hospital, Manado, Indonesia.
Phytother Res ; 38(2): 856-879, 2024 Feb.
Article em En | MEDLINE | ID: mdl-38084816
Burns can cause inflammation and delayed healing, necessitating alternative therapies due to the limitations of conventional treatments. Propolis, a natural bee-produced substance, has shown promise in facilitating burn healing. This literature review provides a comprehensive overview of propolis' mechanisms of action, wound-healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising candidate for managing skin burn injuries. It helps prevent infections, neutralize harmful free radicals, and promote a well-balanced inflammatory response. Moreover, propolis aids in wound closure, tissue regeneration, collagen synthesis, cellular proliferation, and angiogenesis, contributing to tissue regeneration and remodeling. The article discusses various propolis extracts, extraction methods, chemical composition, and optimized formulations like ointments and creams for burn wound treatment. Considerations regarding dosage and safety are addressed. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages. Nevertheless, propolis' natural origin and demonstrated benefits make it a compelling avenue for burn care exploration, potentially complementing existing therapies and improving burn management outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Queimaduras / Anti-Infecciosos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Queimaduras / Anti-Infecciosos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article