O-GlcNAcylation: the sweet side of epigenetics.
Epigenetics Chromatin
; 16(1): 49, 2023 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-38093337
ABSTRACT
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylation. These epigenetic modifications can influence chromatin structure and function without altering the DNA sequence. Histones can also undergo post-translational O-GlcNAcylation, a rather understudied modification that plays critical roles in almost all biological processes and is added and removed by O-linked N-acetylglucosamine transferase and O-GlcNAcase, respectively. This review provides a current overview of our knowledge of how O-GlcNAcylation impacts the histone code both directly and by regulating other chromatin modifying enzymes. This highlights the pivotal emerging role of O-GlcNAcylation as an essential epigenetic marker.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Processamento de Proteína Pós-Traducional
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article