Comparative analysis of diagnostic assays for scrub typhus: Unveiling enhanced approaches for accurate detection.
J Microbiol Methods
; 216: 106875, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-38101580
ABSTRACT
The study comparatively evaluated serological assays, namely, Weil Felix assay, and IgM ELISA with the gold-standard immunofluorescence test (IFAT) for the sensitive and specific serodiagnosis of scrub typhus infection in occupationally exposed groups of humans. A total of 78 serum samples collected from persons affected with various ailments and belonging to different risk groups were screened in the study. Out of the 78 serum samples tested, a total of 17, 26, and 47 samples turned out to be positive by IFAT, IgM ELISA, and Weil Felix test, respectively. The Weil Felix assay could not serve as an ideal test for screening scrub typhus infection owing to its poor sensitivity and specificity in comparison with IFAT. IgM-ELISA could be an initial screening test to detect scrub typhus suspected patient in limited resource settings.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientia tsutsugamushi
/
Tifo por Ácaros
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article