Naringenin, Hesperidin and Quercetin Ameliorate Radiation-Induced Damage In Rats: In Vivo And In Silico Evaluations.
Chem Biodivers
; 21(2): e202301613, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-38105348
ABSTRACT
In this study, we sought to determine how well naringenin, hesperidin, and quercetin prevented damage brought on by radiotherapy. During the investigation, 48 adult female Sprague Dawley rats were used. Eight groups of eight rats each were formed by randomly assigning the rats to the groups. The normal control group was represented by Groupâ
1. Groupâ
2 rats were those that received a dose of 15â
Gray (Gy) of radiotherapy. The rats assigned to Groupâ
3 received only Naringenin, whereas those assigned to Groupâ
4 received only quercetine, and those assigned to Groupâ
5 received only hesperidin. Rats in Groupâ
6, 7 and 8 were received naringenin, quarcetin and hesperidin at a dose of 50â
mg/kg daily for one week prior to radiotheraphy exposition. After radiotheraphy and phenolic compounds rats were sacrificed and some metabolic enzyme (aldose reductase (AR), sorbitol dehydrogenase (SDH), paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and glutathione S-transferase (GST)) activity was determined in eye and brain tissues. It was found that phenolic compounds have protective effect against radiation-induced damage because of their anti-diabetic antioxidant and anti-inflammatory properties. In addition, hesperidin was found to be superior to quercetin and naringenin in terms of enzyme activity efficacy. Furthermore, hesperidin exhibited favorable binding affinity for BChE in silico compared to other enzymes.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavanonas
/
Hesperidina
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article