Exosome-derived miR-5p-72106_14 in vascular endothelial cells regulates fate determination of BMSCs.
Toxicol Appl Pharmacol
; 482: 116793, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-38123076
ABSTRACT
Vascular endothelial cells have recently been shown to be associated with osteogenic activity. However, the mechanism of vascular endothelial cells promoting osteogenesis is unclear. Here, we found that exosomes secreted from human microvascular endothelial cells (HMEC-1) promoted osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibited adipogenic differentiation. Aged and ovariectomy mice treated with exosomes showed increased bone formation and decreased lipid accumulation in the bone marrow cavity. Additionally, we screened out novel exosomal miR-5p-72106_14 by miRNA-seq and confirmed that miR-5p-72106_14 promoted osteogenic differentiation and inhibited adipogenic differentiation of BMSCs by inhibiting STAT1. Our results suggest that vascular endothelial cell-derived exosomes are involved in BMSC differentiation and exosomal miR-5p-72106_14 is a major factor in regulating fate determination of BMSCs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
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Exossomos
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Células-Tronco Mesenquimais
Limite:
Aged
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Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article