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Peripheral clock gene oscillations are perturbed in neonatal and adult rat offspring raised under adverse limited bedding conditions.
Walker, Claire-Dominique; Delorme, Tara C; Kiessling, Silke; Long, Hong; Cermakian, Nicolas.
Afiliação
  • Walker CD; Douglas Mental Health University Institute, 6875 Lasalle Blvd, Montreal, QC, H4H 1R3, Canada. dominique.walker@douglas.mcgill.ca.
  • Delorme TC; Dept of Psychiatry, McGill University, Montreal, QC, Canada. dominique.walker@douglas.mcgill.ca.
  • Kiessling S; Douglas Mental Health University Institute, 6875 Lasalle Blvd, Montreal, QC, H4H 1R3, Canada.
  • Long H; Faculty of Health and Medical Sciences, University of Surrey, Stag Hill Campus, Guildford, GU27XH, UK.
  • Cermakian N; Douglas Mental Health University Institute, 6875 Lasalle Blvd, Montreal, QC, H4H 1R3, Canada.
Sci Rep ; 13(1): 22886, 2023 12 21.
Article em En | MEDLINE | ID: mdl-38129480
ABSTRACT
Circadian (24-h) rhythms in the suprachiasmatic nucleus (SCN) are established in utero in rodents, but rhythmicity of peripheral circadian clocks appears later in postnatal development. Since peripheral oscillators can be influenced by maternal feeding and behavior, we investigated whether exposure to the adverse environmental conditions of limited bedding (LB) during postnatal life would alter rhythmicity in the SCN, adrenal gland and liver in neonatal (postnatal day PND10), juvenile (PND28) and adult rats. We also examined locomotor activity in adults. Limited bedding increased nursing time and slightly increased fragmentation of maternal behavior. Exposure to LB reduced the amplitude of Per2 in the SCN on PND10. Adrenal clock gene expression (Bmal1, Per2, Cry1, Rev-erbα, Dbp) and corticosterone secretion were rhythmic at all ages in NB offspring, whereas rhythmicity of Bmal1, Cry1 and corticosterone was abolished in neonatal LB pups. Circadian gene expression in the adrenal and liver was well established by PND28. In adults, liver expression of several circadian genes was increased at specific daytimes by LB and the microstructure of locomotor behavior was altered. Thus, changes in maternal care and behavior might provide important signals to the maturing peripheral oscillators and modify, in particular their output functions in the long-term.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Relógios Circadianos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ritmo Circadiano / Relógios Circadianos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article