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Association between macronutrients intake and liver dysfunction among tuberculosis patients in rural China.
Zhao, Liangjie; Li, Mingxin; Li, Yue; Hao, Haibo; Zhao, Shanliang; Ma, Aiguo; Cai, Jing.
Afiliação
  • Zhao L; Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.
  • Li M; Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, China.
  • Li Y; Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.
  • Hao H; Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, China.
  • Zhao S; Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao, China.
  • Ma A; Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, China.
  • Cai J; Department of Clinical Nutrition, Yantai Yuhuangding Hospital, Yantai, China.
Asia Pac J Clin Nutr ; 32(4): 444-459, 2023 Dec.
Article em En | MEDLINE | ID: mdl-38135480
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Macronutrients play a vital role in liver dysfunction and affect tuberculosis treatment and prognosis. However, macronutrients intake was inadequate for most tuberculosis patients. This study aimed to clarify the associations between macronutrients intake or energy percentages and liver dys-function in tuberculosis patients. METHODS AND STUDY

DESIGN:

In this cross-sectional study, 2581 active tu-berculosis patients aged ≥18 years were included from local tuberculosis clinics in Linyi, China. Macronutrients intake and energy percentages were assessed by 24-hour dietary recalls. The concentration of alanine transferase (ALT) or aspartate transaminase (AST) greater than 40 U/L was defined as liver dysfunction. A restricted cubic spline (RCS) was applied to determine the dose-response relationships.

RESULTS:

Liver dysfunction was assessed for 14.6% (377 patients) of tuberculosis patients. Higher protein (Q2-Q4 in model 1 and 2) or fat intake and fat-to-energy percentages and lower carbohydrate-to-energy percentages (Q4 in model 1) were associated with a decreased incidence of liver dysfunction (p-trend < 0.05). Among those who were male, normal BMI, or consumed energy <1636 kcal/d, inverse associations between protein or fat intake and the risks of liver dysfunction in models were suggested (p-trend < 0.05). Moreover, J-shaped curves in RCS were evident in liver dysfunction tuberculosis patients with protein or fat intake (p-nonlinearity < 0.05). Conclu-sions Significant linear associations between macronutrients intake or energy percentages and liver dysfunction prevalence were found only in male, normal BMI, or less energy intake patients. The shapes of liver dysfunction-morbidity differed significantly by macronutrients intake or energy percentage.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Hepatopatias Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Hepatopatias Limite: Adolescent / Adult / Female / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article