Innovative Experimental Ultrasound and US-Related Techniques Using the Murine Model in Pancreatic Ductal Adenocarcinoma: A Systematic Review.
J Clin Med
; 12(24)2023 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-38137745
ABSTRACT
Pancreatic ductal adenocarcinoma (PDAC) is a cancer with one of the highest mortality rates in the world. Several studies have been conductedusing preclinical experiments in mice to find new therapeutic strategies. Experimental ultrasound, in expert hands, is a safe, multifaceted, and relatively not-expensive device that helps researchers in several ways. In this systematic review, we propose a summary of the applications of ultrasonography in a preclinical mouse model of PDAC. Eighty-eight studies met our inclusion criteria. The included studies could be divided into seven main topics ultrasound in pancreatic cancer diagnosis and progression (n 21); dynamic contrast-enhanced ultrasound (DCE-US) (n 5); microbubble ultra-sound-mediated drug delivery; focused ultrasound (n 23); sonodynamic therapy (SDT) (n 7); harmonic motion elastography (HME) and shear wave elastography (SWE) (n 6); ultrasound-guided procedures (n 9). In six cases, the articles fit into two or more sections. In conclusion, ultrasound can be a really useful, eclectic, and ductile tool in different diagnostic areas, not only regarding diagnosis but also in therapy, pharmacological and interventional treatment, and follow-up. All these multiple possibilities of use certainly represent a good starting point for the effective and wide use of murine ultrasonography in the study and comprehensive evaluation of pancreatic cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Systematic_reviews
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article