Kelch-like Protein 11 (KLHL11) Antibodies in Children With Seizures of Undetermined Cause.
In Vivo
; 38(1): 351-357, 2024.
Article
em En
| MEDLINE
| ID: mdl-38148071
ABSTRACT
BACKGROUND/AIM:
Kelch-like protein 11 (KLHL11)-antibody may be found in paraneoplastic neurological disorders presenting with epileptic seizures. The aim of this study was to investigate the prevalence and clinical significance of KLHL11-antibody in epilepsy. PATIENTS ANDMETHODS:
Sera of 42 pediatric and 59 adult patients with seizures of undetermined cause were screened using a cell-based assay.RESULTS:
KLHL11-antibody was found in three of 168 control patients with paraneoplastic neurological disorders and four pediatric patients (4-8-year-old, 2 boys/2 girls) with seizures of unknown cause presenting with myoclonic-atonic epilepsy, generalized epilepsy or childhood epilepsy with centrotemporal spikes. In these four cases, seizures continued for 2-7 months, responded promptly and favorably to conventional anti-seizure drugs and did not recur in follow-up durations ranging between 2-5 years. Patients had normal brain MRI findings and motor-mental development before and after seizures. KLHL11-antibody was not detected in adult epilepsy patients with undetermined cause, MOG antibody-positive patients and healthy controls.CONCLUSION:
KLHL11-antibody may be detected in pediatric epilepsy patients with a relatively benign disease course.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eletroencefalografia
/
Epilepsia
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article