Tempol improves aortic mechanics in a mouse model of hypertension.
J Biomech
; 162: 111911, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-38150954
ABSTRACT
Hypertension-induced arterial remodeling is thought to be a response to increases in both mechanical stress and oxidative stress. The superoxide dismutase mimetic Tempol has been shown to reduce adverse aortic remodeling in multiple murine models of hypertension but in the absence of a detailed assessment of the biaxial biomechanics. We show that concurrent treatment with Tempol in a common mouse model of systemic hypertension results in modest reductions in both wall thickening and circumferential material stiffness that yet work together to achieve a significant reduction in calculated aortic pulse wave velocity. Reducing elevated values of pulse wave velocity engenders multiple benefits to cardiovascular function.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rigidez Vascular
/
Hipertensão
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article