Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients.
Arch Bronconeumol
; 60(2): 88-94, 2024 Feb.
Article
em En, Es
| MEDLINE
| ID: mdl-38160163
ABSTRACT
INTRODUCTION:
The aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases.METHODS:
We used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient.RESULTS:
A total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR 1.38; 95% CI 1.21-1.57), being in stage III or IV (OR 1.32; 95% CI 1.08-1.62), not having comorbidities (OR 5.21; 95% CI 4.59-5.91), presenting with symptoms at diagnosis (OR 1.53; 95% CI 1.29-1.81), and having ALK translocation (OR 7.61; 95% CI 1.25-46.32) and HER2 mutation (OR 5.71; 95% CI 1.34-24.33), compared with subjects ≥50 years. Among subjects <35 years old (n=61), our study observed a higher proportion of women (59.0% vs. 26.6%; p<0.001), never smokers (45.8% vs. 10.3%; p<0.001), no comorbidities (21.3% vs. 74.0%; p<0.001); ALK translocation (33.3% vs. 4.4%; p<0.001) and ROS1 mutation (14.3% vs. 2.3%; p=0.01), compared with subjects ≥35 years.CONCLUSIONS:
Lung cancer displays differences by age at diagnosis which may have important implications for its clinical management.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pulmonares
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
/
Es
Ano de publicação:
2024
Tipo de documento:
Article