Isthmin-1: A critical regulator of branching morphogenesis and metanephric mesenchyme condensation during early kidney development.
Bioessays
; 46(3): e2300189, 2024 03.
Article
em En
| MEDLINE
| ID: mdl-38161234
ABSTRACT
Isthmin-1 (Ism1) was first described to be syn-expressed with Fgf8 in Xenopus. However, its biological role has not been elucidated until recent years. Despite of accumulated evidence that Ism1 participates in angiogenesis, tumor invasion, macrophage apoptosis, and glucose metabolism, the cognate receptors for Ism1 remain largely unknown. Ism1 deficiency in mice results in renal agenesis (RA) with a transient loss of Gdnf transcription and impaired mesenchyme condensation at E11.5. Ism1 binds to and activates Integrin α8ß1 to positively regulate Gdnf/Ret signaling, thus promoting mesenchyme condensation and ureteric epithelium branching morphogenesis. Here, we propose the hypothesis underlying the mechanism by which Ism1 regulates branching morphogenesis during early kidney development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureter
/
Estruturas Embrionárias
/
Fator Neurotrófico Derivado de Linhagem de Célula Glial
/
Néfrons
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article