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Self-Assembly of Unusually Stable Thermotropic Network Phases by Cellobiose-Based Guerbet Glycolipids.
Das, Soumi; Zheng, Caini; Lodge, Timothy P; Siepmann, J Ilja; Mahanthappa, Mahesh K; Calabrese, Michelle A; Reineke, Theresa M.
Afiliação
  • Das S; Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St SE, Minneapolis, Minnesota 55455, United States.
  • Zheng C; Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St SE, Minneapolis, Minnesota 55455, United States.
  • Lodge TP; Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St SE, Minneapolis, Minnesota 55455, United States.
  • Siepmann JI; Department of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, 421 Washington Avenue SE #151, Minneapolis, Minnesota 55455, United States.
  • Mahanthappa MK; Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St SE, Minneapolis, Minnesota 55455, United States.
  • Calabrese MA; Department of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, 421 Washington Avenue SE #151, Minneapolis, Minnesota 55455, United States.
  • Reineke TM; Department of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, 421 Washington Avenue SE #151, Minneapolis, Minnesota 55455, United States.
Biomacromolecules ; 25(2): 1291-1302, 2024 Feb 12.
Article em En | MEDLINE | ID: mdl-38170593
ABSTRACT
Bicontinuous thermotropic liquid crystal (LC) materials, e.g., double gyroid (DG) phases, have garnered significant attention due to the potential utility of their 3D network structures in wide-ranging applications. However, the utility of these materials is significantly constrained by the lack of robust molecular design rules for shape-filling amphiphiles that spontaneously adopt the saddle curvatures required to access these useful supramolecular assemblies. Toward this aim, we synthesized anomerically pure Guerbet-type glycolipids bearing cellobiose head groups and branched alkyl tails and studied their thermotropic LC self-assembly. Using a combination of differential scanning calorimetry, polarized optical microscopy, and small-angle X-ray scattering, our studies demonstrate that Guerbet cellobiosides exhibit a strong propensity to self-assemble into DG morphologies over wide thermotropic phase windows. The stabilities of these assemblies sensitively depend on the branched alkyl tail structure and the anomeric configuration of the glycolipid in a previously unrecognized manner. Complementary molecular simulations furnish detailed insights into the observed self-assembly characteristics, thus unveiling molecular motifs that foster network phase self-assembly that will enable future designs and applications of network LC materials.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Celobiose / Cristais Líquidos Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Celobiose / Cristais Líquidos Idioma: En Ano de publicação: 2024 Tipo de documento: Article